Few studies revealed that clozapine affects the increase of IL-6 in the plasma during the 2 weeks, but not the longer treatment (125–128), while other, comprehensive studies showed that atypical antipsychotic risperidone or the typical antipsychotic haloperidol do not significantly affect serum levels of IL-6 in patients with schizophrenia (117, 129). This evidence concerns the gene IL6 and schizophrenia.