PRMT1 and amyotrophic lateral sclerosis: For example, genetic ablation of the fly homolog of PRMT1 exacerbated the neurodegeneration induced by overexpression of FUS in a Drosophila model of FUS-ALS (Scaramuzzino et al., 2013), whereas PRMT1 knockdown in cultured murine motor neurons has differential effects on cytosolic FUS inclusion abundance, which depend, in part, on the timing and method employed to inhibit PRMT1 (Tradewell et al., 2012).