Considering the prevalence of sleep alterations and fatigue as a common symptom of gliomas, the anatomical compromise of the master clock and optic tract in hypothalamic gliomas, and the alteration of molecules relevant for the circadian pacemaker in the tumor microenvironment, we hypothesized that this pathology could impact circadian timekeeping, and such alterations could be a valuable tool at the time of diagnosis. Here, CLOCK is linked to central nervous system cancer.