For example, while loss-of-function variants were limited to the RD, new variants in the ankyrin-B MBD have shed light on new phenotypes associated with “ankyrin-B syndrome.” Recently, a novel MBD variant in the ANK2 gene (p.S646F) was identified in two Gitxan families with LQTS phenotypes by the Swayne and Arbour groups (Swayne et al., 2017). This evidence concerns the gene ANK2 and familial long QT syndrome.