The function of tuft cells was rather unclear until three studies recently demonstrated that tuft cells initiated type II immune response by secreting the cytokine IL25, IL33, and TSLP (thymic stromal lymphopoietin) following parasite infections in the murine intestine (Gerbe et al., 2016; Howitt et al., 2016; von Moltke et al., 2016). Here, TSLP is linked to parasitic infectious disease.