Our results, indicating activation of caspase-8 by AD0157, as well as a decrease in the toxicity of this compound in the presence of a caspase-8 inhibitor, although preliminary, suggest that activation of the extrinsic pathway of apoptosis could be related to the AD0157 death-inducing activity on leukemia cells (Figure 9). This evidence concerns the gene CASP8 and leukemia.