The incubation with AD0157 at concentrations of 1 μM or higher (5 and 10 μM), significantly enhanced the activities of the initiator caspase-8 (Figure 5A) and caspase-9 (Figure 5B), and the effector caspases-3/-7 in a dose-dependent manner (Figure 5C) in the different leukemia cells. The gene discussed is CASP8; the disease is leukemia.