Pharmacogenomic profiles can show a predisposition to a higher neutropenia and neuropathy risk by reveling higher transmembrane expression of the ABCB1 (3435TT and 2677TT/AA), variant phenotype, conferring the excessive extrusion of taxane from neoplastic cells and causing high plasma concentration. The gene discussed is ABCB1; the disease is Decreased total neutrophil count.