In fact, potential therapies for the treatment of atherosclerosis such as mucosal administration of athero-antigens (HSP 65, oxLDL, apoB-100 peptides) have shown increments in production of IL-10, IL-4 and TGF-β (Harats et al., 2002; van Puijvelde et al., 2006; Klingenberg et al., 2010). Here, IL10 is linked to atherosclerosis.