Low-, moderate- and high-dose of GXDSF treated group could ameliorate fibrosis by reducing the levels of collagen I (P < 0.001), collagen III (P < 0.001) and α-SMA (P < 0.001) and decreasing the left ventricular fibrosis percentage (P < 0.05). The gene discussed is ACTA1; the disease is fibrosis.