RHO and cancer: By inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, simvastatin and other statin family members have been shown to limit geranylgeranylation, primarily of Rho proteins, in breast, colorectal cancers and melanoma, thence limiting cancer cell invasion (Collisson et al., 2003; Denoyelle et al., 2003; Poynter et al., 2005).