Though protection against Aβ toxicity through enforced Xbp1 expression in a Drosophila melanogaster AD model is attributed to reduction in the release of Ca2+ from ER (Casas-Tinto et al., 2011), a similar effect in Caenorhabditis elegans AD model is correlated with augmented stress levels and enhanced autophagy (Safra et al., 2013). This evidence concerns the gene XBP1 and Alzheimer disease.