INS and memory impairment: The ICV-STZ rats develop insulin resistant brains state associated with sAD like neuropathological changes and memory impairment (Carro and Torres-Aleman, 2004; Valente et al., 2010; Agrawal et al., 2011; Bitel et al., 2012; Chen et al., 2013; Iqbal et al., 2013; Kamat et al., 2016).