Indeed, it was shown that the stimulation of 5-HT7 serotonin receptors in post-synaptic compartments reverses mGluR-LTD in hippocampal slices of FXS mouse brains, suggesting that 5-HT7 receptor agonists might be envisaged as novel therapeutic tools for FXS (Costa et al., 2012). Here, HTR7 is linked to fragile X syndrome.