HOMER1 and major depressive disorder: Moreover, AAV-mediated Homer1a over-expression within the NAC increased the float latency in both Homer1a+/+ and Homer1a-/- mice (Figure 6C), arguing that Homer1a induction within both the cell body and terminal regions of the corticoaccumbens projections actively gates a depressive-like phenotype – a finding in line with associations between variants in the Homer1 gene and major depressive disorder (e.g., Rietschel et al., 2010; Strauss et al., 2012; Rao et al., 2017).