Indeed, cell adhesion proteins, including those coded by CHL1 and ITGB3, were shown to play key roles in neurogenesis and synaptogenesis, which in turn, are crucial for remission from depression (Thomas and Peterson, 2008; Hanson et al., 2011; Danzer, 2012; Eisch and Petrik, 2012; Eyre and Baune, 2012; Bambico and Belzung, 2013; Mateus-Pinheiro et al., 2013; Duman, 2014; Duman and Duman, 2015). This evidence concerns the gene CHL1 and major depressive disorder.