Since miR-34b and miR-34c are shown to target multiple genes in PD including PRKN and PARK7 (Miñones-Moyano et al., 2011), SNCA (Kabaria et al., 2015b), MAPT (Wu H. et al., 2013), these miRNAs are potentially useful to detect early dysregulation and onset of PD progression. This evidence concerns the gene SNCA and Parkinson disease.