The neuropathological hallmark of PD is the deposition of the intracytoplasmic protein inclusions known as Lewy bodies (LB) that are composed of various molecules including α-synuclein (protein product of SNCA gene) aggregates, which is responsible for the loss of DA neurons in the midbrain of substantia nigra (Spillantini et al., 1997; Wakabayashi et al., 2007; Longhena et al., 2017). Here, SNCA is linked to Parkinson disease.