Given that some of these microRNAs were found to be significantly altered in LOPD studies (Table 1), thus this neuroprotection of miRNAs network in regulating α-synuclein protein level may therefore potentially be used as biomarker for PD progression, though their roles in differentiating EOPD would requires more investigations, as there was no comparison of EOPD in those previous LOPD studies (Table 1). The gene discussed is SNCA; the disease is Parkinson disease.