One such is in the comparison between LOPD patients and normal controls, miR-128 expression in CSF samples was found to be reduced (Burgos et al., 2014) and miR-128 can directly bind to CYP2D6 mRNA and suppression its expression (Li et al., 2015), which may indicates that CYP2D6 expression was up-regulated in the LOPD patients, consistent with the needs of CYP2D6 to metabolize the neurotoxins in PD. The gene discussed is CYP2D6; the disease is Parkinson disease.