Whereas, miR-7 that also regulates NLRP3 (Zhou et al., 2016) and proto-oncogene, NF-kB subunit/p65 protein (RELA) (Choi et al., 2014), its expression was reduced in the brain tissues of LOPD patients (Tatura et al., 2016) thus indicates a loss of miR-7 neuroprotection in PD progression. Here, RELA is linked to Parkinson disease.