Furthermore, from the known mutations in PD, PRKN, PINK1, NFE2L2, A2M, and PARK7 genes (mitochondrial, oxidative genes and neuro-inflammation) (Krüger et al., 2000; Klein and Westenberger, 2012; Lin and Farrer, 2014; Todorovic et al., 2015) and other genes like DRD3 (Hassan et al., 2016) and HNMT (Yang X. et al., 2015) were showed to be associated with EOPD. This evidence concerns the gene A2M and Parkinson disease.