Proinflammatory cytokines such as IL-1β, IL-6, and TNF-α are not only key mediators in rheumatoid arthritis, they are also present in the joint in human and experimental OA (Bondeson et al., 2010; Im et al., 2010; Goldring and Otero, 2011; Orita et al., 2011a; Konttinen et al., 2012; Harkey et al., 2015; Larsson et al., 2015). This evidence concerns the gene IL6 and rheumatoid arthritis.