The importance of trkB, β2-chain laminins and voltage-gated calcium channels for neuromuscular synapse function with respect to neurotransmission and functional acetylcholine receptors is also illustrated in patients with congenital myasthenic syndromes, Lambert-Eaton myasthenic syndrome (LEMS) or myasthenia gravis (MG) (Punga and Ruegg, 2012; Shi et al., 2012). Here, LAMB2 is linked to Congenital myasthenic syndromes.