Recently, there is a wealth of studies have shown that inflammasome is involved in the pathological process of various sterile inflammatory disorders, such as gout, Crohn disease, systemic-onset juvenile arthritis, and cryopyrin-associated periodic syndromes (Walsh et al., 2014; Coll et al., 2015; Zhu et al., 2017). The gene discussed is NLRP3; the disease is Crohn disease.