SOD1 and amyotrophic lateral sclerosis: Dendritic vacuoles, derived from degenerating mitochondria, are prevalent in lumbar MNs from P60 onward in SOD1 mice (Kong and Xu, 1998; Vinsant et al., 2013) and in the dendrites of human Betz cells in ALS post mortem tissue (Genç et al., 2017).