Corticotropin releasing factor (CRF) is a neuropeptide commonly implicated in fear and anxiety (Liang et al., 1992; Basso et al., 1999; Radulovic et al., 1999; Kikusui et al., 2000; Takahashi, 2001; Nemeroff, 2004; Bale, 2005; Lukkes et al., 2009; Vuong et al., 2010; Bledsoe et al., 2011). The gene discussed is CRH; the disease is Anxiety.