Tumor thrombus (OR = 3.591, 95% CI: 1.438–8.971, p = 0.006), UCSF criteria (OR = 3.922, 95% CI: 1.515–10.152, p = 0.005), and recipient IL-15 rs10519613 genotypes (CA/AA versus CC; OR = 5.143, 95% CI: 1.636–16.168, p = 0.005) were independent predictive factors of HCC recurrence. The gene discussed is IL15; the disease is hepatocellular carcinoma.