The incidence of HCC recurrence was significantly higher for patients with recipient IL-15 rs10519613 CA/AA genotypes than for those with the CC genotype (p < 0.001), and patients with the recipient IL-15 rs10519613 A allele had higher HCC recurrence than those with the C allele (p < 0.001). Here, IL15 is linked to hepatocellular carcinoma.