In univariate analysis, tumor size (p < 0.001), tumor thrombus (p < 0.001), TMN stage (p = 0.004), UCSF criteria (p = 0.002), and recipient IL-15 rs10519613 genotypes (CA/AA versus CC, p = 0.001) were significantly associated with an increased risk of HCC recurrence. The gene discussed is IL15; the disease is hepatocellular carcinoma.