These compounds again appeared to silence HMGA2 in a dose dependent manner (Fig. 5C), but also these compounds induced typical CREB target genes such as FOSB and CFOS in Huh7 cells and ATF3, FOSB and CFOS in HL60, MOLM13 and THP-1 cells (AML lines) (Fig. 5D and E). This evidence concerns the gene CREB1 and acute myeloid leukemia.