Apparently, negative regulation of prosurvival Akt kinase as well as HIF-1α by FQ plays an important role in FQ-induced prostate cancer cell death in serum starved and hypoxic conditions, as both Akt and HIF-1α have been previously reported to be key survival factors for serum- or oxygen-deprived prostate cancer cells22–24. This evidence concerns the gene HIF1A and Familial prostate cancer.