IRS1 and breast carcinoma: Except for DNMT1, accumulating evidence indicates that miR-152 targets on multiple oncogenes like PKM2, IRS-1 and IGF-1R in human breast cancer, and inhibits a variety of cellular functions, including proliferation, angiogenesis and migration, suggesting that miR-152 may potentially function as a tumor suppressor in breast cancer8,10,14.