Because (1) the tumorigenesis of most cancer types are similar; (2) cancer genes bearing mutations in EC are similar to other cancer types2,12–14, e.g., TP53, PIK3CA and KRAS; and (3) some mutational signatures of cancers are similar18, we wondered how well GATKcan trained by partial TCGA EC tumors can be applied to other cancer types. The gene discussed is KRAS; the disease is cancer.