Given that the number of known druggable targets for the treatment of cognitive impairments associated with psychiatric, neurological, and neurodevelopmental disorders is greatly limited, and that discovery of new lead candidates is needed to find more effective therapies, we considered that the connection that our screen uncovered between pharmacological agents with neuroprotective/nootropic qualities and nuclear Arc accumulation demanded further scrutiny. The gene discussed is ARC; the disease is Cognitive impairment.