CCND1 and neoplasm: Similarly, several proteins such as Bcl-X Retinoblastoma (Rb) oncogene and Cyclin D1 were also found to have a differential expression in OVC.19, 20 However Ogawa et al. (2004) observed no obvious differences in p53 protein expression between VC and well-differentiated SCC in proliferative activity of tumor cells.16