The elevated expression of the notch signaling molecules (Notch 1–4 receptors, Delta like 1, Delta like 3, Delta like 4, Jagged 1 and Jagged 2 ligands) has been considered to be one of the critical event in several malignancies.7, 8, 9 Importantly, accumulative evidence has shown that constitutive activation of Notch4 receptor, one of the key receptor molecules of the Notch signaling family has been associated with several cancer pathogenesis. Here, NOTCH1 is linked to cancer.