FLT4 and colorectal cancer: A study designed by Kawakami et al. [5] found that the positive rate of VEGFR–3 in colorectal cancer tissues was 79.2%; meanwhile, his study confirmed that there was no correlation between the expression level of VEGFR–3 in cancer tissues and lymph node involvement; however, different conclusion was made by some other professors: some studies showed that an increased rate of lymph nodes involvement was related to the higher expression level of VEGFR–3 in colorectal cancer tissues [17, 18].