Some similar or different results were found based on our study; all of the four markers had the high positive expression rates not only in tumor tissues but also in para-cancerous cancer tissues, and the expression levels of LYVE–1 and VEGFR–3 was higher in para-cancerous tissues than that in tumor tissues, whereas the higher expression levels of Podoplanin and Prox–1 was found in tumor tissues. The gene discussed is PDPN; the disease is cancer.