Interestingly, 380 of the 555 age-regulated genes in Drosophila photoreceptors have identifiable human homologs, six of which are associated with retinal disease (RetNet: http://www.sph.uth.tmc.edu/RetNet/): Cyp4c3 (CYP4V2), l(1)G0007 (DHX38), CG5291 (PDZD7), CG3662 (ITM2B), krz (SAG), and Cct1 (PCYT1A). The gene discussed is PDZD7; the disease is Abnormal retinal morphology.