B-type natriuretic peptide (BNP) and its cleavage fragment, NT-proBNP, are known to be influenced by preload and ventricular abnormalities and are good markers of myocardial damage and stress in patients with renal failure.[22] Compared with BNP whose clearance occurs in the kidneys and other organs, NT-proBNP is only cleared by the renal system.[23] In addition, in patients with heart failure, renal disorders are confirmed by depletion of plasma NT-proBNP. This evidence concerns the gene NPPB and heart failure.