For the opposite case, u(MA, HA), the gene DSPP, related to deafness and tooth abnormalities (dentin dysplasia and dentinogenesis imperfecta) were found alongside PLAG1, DCLRE1C and PLCB2 to be associated with adenomas, severe immunodeficiency and platelet deficiency respectively. This evidence concerns the gene DSPP and immunodeficiency disease.