KIT and seminoma: Previous work by us and others has shown the involvement of RTK signalling in seminomas (SEs) by showing that the gene encoding KIT is amplified (21% of SEs) 10, 11, expressed (78–100% of SEs) 12, 13, 14, 15, and mutated (10–25% of SEs), together suggesting a strong selection pressure for KIT signalling in SE 16, 17, 18.