TP53 and cancer: The drug combination induced cancer cell death through caspase activation [80,82,83,84], generation of reactive oxygen species (ROS) [79,80,81,82,85], enhanced histone acetylation [86,87], aggresome disruption [88], NF-κB inactivation [79,80,82,83,85], p53 activation, p21WAF1 up-regulation [79,81,82,84], c-Jun NH2-terminal kinase (JNK) activation [79,83] and mitochondrial membrane dysfunction [79,82,83,84].