LGALS3 and osteoradionecrosis: In addition, Reid et al. reported that BRONJ was associated to increased osteogenic differentiation of mucoperiosteal progenitors, anergy of the affected tissues, and increased galectin-3 expression in the periosteum and fibrous tissue stroma cells [97], thereby differing from osteoradionecrosis-related mucoperiosteal tissue, which was characterized by local inflammation and significantly less galectin-3 staining [98].