LGALS3 and diabetes mellitus: This concept is strengthened by the evidence that, in addition to its role in osteogenesis, (a) galectin-3 is able to stimulate osteogenic differentiation of MSCs [46]; (b) in osteoblast lineage cells [43,44,45], it acts as a receptor capable of degrading AGEs, which have been implicated in age-dependent [118] and diabetes-associated [119] bone fragility; and (c) it may favor resolution of chronic inflammation [20], also in the bone tissue [20,97,98,99].