SMN2 and amyotrophic lateral sclerosis: In fact, SMN binds directly to proteins relevant for miRNA generation and functionality, specifically fragile X mental retardation protein (FMRP), KH‐type splicing regulatory protein (KSRP) and fused in sarcoma/translocated in liposarcoma (FUS/TLS), which is one of the most frequent genetic causes of juvenile amyotrophic lateral sclerosis (ALS) 17, 18, 19.