Since the correlation between the expression of NDUFA4L2 and ELK1 is very weak, we further performed the knockdown of ELK1 and detected the levels of NDUFA4L2 in ccRCC cells 786-O and ACHN to elucidate the direct regulatory role of ELK1 on NDUFA4L2 expression. This evidence concerns the gene COXFA4L2 and nonpapillary renal cell carcinoma.