Several immunosuppressive leukocytes, including myeloid derived suppressor cells (MDSCs), tumor associated macrophages (TAMs) and regulatory T cells (Tregs) resident at the TME sites, release immunosuppressive cytokines, such as TGF-β and IL-10, which promote tumor growth, metastasis, and angiogenesis (Cesana et al., 2006). This evidence concerns the gene TGFB1 and neoplasm.