Besides, it was also proved that co-administration of G-Rg5/G-Rk1 with a ratio 1:1 have various effects such as improving the cognitive performance in ethanol-induced amnesia in mice (Bao et al., 2005; Jing et al., 2006), inhibiting the exotoxic and oxidative stress-induced neuronal cell damage (Bao et al., 2005), and stimulating the mineralization of the extracellular matrix of osteoblasts (Siddiqi et al., 2014). Here, GRK1 is linked to amnesia.