NFKB1 and Autoimmunity: Regulatory T (Treg) cells, generated along with thymocyte development or through CD4+ T-cell differentiation, are instrumental for controlling immune responses to prevent autoimmunity and chronic inflammation.46 Although NF-κB is known as a factor that promotes T-cell activation and effector T-cell differentiation, it is increasingly clear that the function of NF-κB in T-cell responses is paradoxical, since it is also involved in the generation of Treg cells.