NF-κB has been implicated in the pathogenesis of a number of inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis, atherosclerosis, systemic lupus erythematosus, type I diabetes, chronic obstructive pulmonary disease and asthma.73 In response to different cellular stimuli, NF-κB plays a complex role in different cell types and in different diseases states. The gene discussed is NFKB1; the disease is type 1 diabetes mellitus.