NFKB1 and multiple sclerosis: These studies have identified a number of NF-κB-related factors as susceptibility candidates, such as RelA, IκBα, IκBz, NIK, Bcl10 and MALT1.110–112 Consistently, both the canonical and noncanonical NF-κB pathways play an important role in the pathogenesis of EAE, a widely used animal model of multiple sclerosis involving immunization of mice with peptides derived from CNS proteins, such as myelin oligodendrocyte glycoprotein.2,113.