Likewise, it has been discovered that activation of AKT pathway stimulates VEGF and MMPs production by cancer cells and pharmacological inhibition of AKT can suppress the expression of VEGF and MMP2 (Karar & Maity, 2011; Kwiatkowska, Kijewska, Lipko, Hibner, & Kaminska, 2011; Tsou et al., 2013). This evidence concerns the gene AKT1 and cancer.