On the other hand, several papers have demonstrated that stimulation of cAMP by its analogues dramatically reduces AKT and mitogen-activated protein kinase (MAPK) activities and leads to apoptosis in cancer cell lines (Ahn, Jung, & Hong, 2005; Tsunoda et al., 2012; Wang, Liu, & Adamo, 2001). This evidence concerns the gene AKT1 and cancer.