NOS3 and placental abruption: Some authors have suggested that Glu298Asp polymorphism in NOS3 gene plays a role in various diseases such as idiopathic male infertility, myocardial infraction, and placental abruption (Gad et al., 2012; Luo, Wen, Zhou, Chen, & Zhang, 2014; Safarinejad et al., 2010; Yoshimura, Yoshimura, Tabata, Yasue, & Okamura, 2001).