The other somatic mutated genes that significantly affected at least 5.3% of differential gene modules included NOD2, RRM1, CSRNP1, SLC4A2, TTLL1 and CNTN1. The genetic alterations of these eight genes were significantly associated with poor survival rates of ccRCC patients (P < 0.054, Supp. This evidence concerns the gene NOD2 and nonpapillary renal cell carcinoma.