Hyperimmunoglobulin E syndrome (HIES) or Job's syndrome was first described by Davis et al. in 1966 [1] as a collection of rare immunodeficiency syndromes usually diagnosed in childhood based on a triad of elevated serum hyperimmunoglobulin E (IgE) levels, chronic dermatitis, recurrent pyogenic infections, or other clinical features that vary based on autosomal dominant or recessive disease [2]. Here, IGHE is linked to hyper-IgE syndrome.