Enforced expression of miR-29b mimics in DCs co-cultured with MM cells or lipopolysaccharide significantly reduced double-positive CD83/CD86 mature DCs at 48 h (Figure 3a) and, according to molecule activity predictor prediction, a significant downregulation of the surface expression of the costimulatory molecule CD86 and of the immune regulatory antigen B7H3, which is a validated miR-29 target,38 was found (Supplementary Figure 3A). Here, CD276 is linked to Miyoshi myopathy.