To this end, we used the unique SCID-synth-hu model, which recapitulates the huBMM for MM engraftment in a bio-synthetic polymeric scaffold implanted in NOD-SCID mice.35, 36 Following huBMM reconstitution, scaffolds were in fact injected with IL-6/BM-dependent MM cells (INA-6) (Figure 4b). This evidence concerns the gene IL6 and Miyoshi myopathy.