In the general view of miR-29b anti-inflammatory potential, we already reported that its overexpression in osteoclast precursors reduced their bone lytic capability;25 In addition, we observed that enforced expression of miR-29b in MM cells could affect survival and angiogenesis through suppressor of cytokine signaling 1 upregulation, and VEGFA and IL8 downregulation.22, 23, 31, 61 Here we show that miR-29b overexpression in DCs affect their pro-inflammatory and pro-tumor potential through different molecular mechanisms. Here, SOCS1 is linked to neoplasm.