Among others, we found significant upregulation of CCR3, CCR5 and both components of IL-23 receptor (IL12RB1 and IL23RA) in patient-derived MM cells (Figure 5b), whereas both components of the IL-10 receptor were significantly downregulated, thus suggesting a pro-inflammatory unbalancing of the MM niche. According to previous reports,46 we confirmed a significant downregulation of CCR2 (Supplementary Figure 5A). This evidence concerns the gene CCR3 and Miyoshi myopathy.