We observed that the levels of HOMA-IR, fasting insulin, BMI, WC, TG, TC, FBG as well as the prevalence of hypertension and diabetes stepwise increased, while serum total T, E2, SHBG, FSH and LH level stepwise declined with the increasing TyG quartiles (all P for trend < 0.01). The gene discussed is SHBG; the disease is diabetes mellitus.