As described in Table 3, the liner regression results showed that in the model adjusted for age, current smoking status, hypertension and overweight/obesity, the TyG was negatively associated with log-TT, log-E2, log-SHBG, log-FSH and log-LH (all P for < 0.01). The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.