As in human breast cancer cells, Morgana downregulation in 4T1 and E0771 mouse mammary carcinoma cells (Supplementary Fig. 8a, b), whereas not affecting proliferation in vitro (Supplementary Fig. 8c, d), clearly impacted on IκBα phosphorylation (Supplementary Fig. 8e, f) and NF-κB target gene transcription (Supplementary Fig. 8g, h). The gene discussed is CHORDC1; the disease is breast cancer.