NPPA and cardiac hypertrophy: Importantly, both mouse lines were protected from TAC-induced cardiac hypertrophy and functional impairment, showing better heart function than wildtype (Fig. 1b and Supplementary Table 1), reduced myocardial (i.e., heart weight) and cardiac myocyte hypertrophy (Fig. 1c, d) and lower levels of hypertrophy-associated marker genes Nppa and Myh7 (in relation to Myh6) (Fig. 1f).