PDP1 and neoplasm: As Fig. 4 and Supplementary Fig. 11 shows, the 13C labeling patterns were similar between the primary tumor and lymph node lesions for metabolites of glycolysis (cf. 13C3-lactate/pyruvate, Fig. 4b, l and Supplementary Fig. 11b, l), gluconeogenesis (cf. 13C3-G6P, Fig. 4a and Supplementary Fig. 11a), and the Krebs cycle including the anaplerotic PCB (cf. 13C3-citrate/Asp, Fig. 4c, g and Supplementary Fig. 11c, g), ME (cf. 13C1-malate, Fig. 4f and Supplementary Fig. 11f) and canonical PDH-initiated reactions (13C2-citrate/Asp, Fig. 4c, g and Supplementary Fig. 11c, g).