IFNA1 and neoplasm: Another recent study has also shown that the loss of the Hippo pathway kinases large tumour suppressor 1 and 2 (LATS1/2) in tumour cells inhibits tumour growth by nucleic-acid-rich-EVs, which induce a type I interferon response (IFN) via the Toll-like receptors-MYD88/TRIF pathway [29].