The existence of this immunosuppressive niche is reinforced by the activation of DC by tumour-derived EVs [24,32], and by favouring the generation of myeloid-derived suppressor cells (MDSCs), that contain prostaglandin E2 (PGE2), transforming growth factor-β (TGFβ) and heat shock protein 72 (HSP72) in their secreted vesicles [24]. The gene discussed is TGFB1; the disease is neoplasm.